Machine Learning & Data-Driven Methods
Physics-augmented deep learning, reinforcement learning for security-critical control, and information-theoretically optimal learning of dynamical systems.
Overview
The machine-learning program in the lab combines modern data-driven methods with the physical models, systems theory, and information-theoretic tools developed in the group’s other areas. The emphasis is on methods that carry guarantees — sample-complexity bounds, physical constraints as inductive bias, and rigorous evaluation against systems-theoretic baselines — rather than purely empirical modeling.
Active threads include:
- Physics-augmented deep learning for classifying single-molecule force-spectroscopy data, connecting deep networks to the mechanical models used in the systems-biology program.
- Machine-learning approaches to topology change estimation in power distribution networks — a bridge between the energy and foundations programs.
- Reinforcement-learning-based vulnerability analysis of electricity markets under cyber-topology attack, contributing to the cyber-physical-security subthread in the energy area.
- Information-theoretically optimal sample complexity of learning dynamical DAGs — foundational bounds on how much data is needed to identify network structure.
- Non-intrusive load monitoring using hybrid classification-regression methods, scalable to high-frequency residential data.
- Support-vector-machine methods for preventing cascading failures in microgrids.
The area works most productively in combination with the others: a paper is often cross-tagged with energy or systems-biology, reflecting that the ML methods are developed to answer a substantive question in an applied domain, not for their own sake.
Recent publications in this area
See all 13 →-
Frequency-Domain Better than Time-Domain for Causal Structure Recovery in Dynamical Systems on Networks
Mohammed Tuhin Rana, Mishfad Shaikh Veedu, James Melbourne, Murti Salapaka
International Conference on Learning Representations (ICLR) · 2026
-
GenUnfold: Rapidly Predict Protein Mechanical Unfolding Trajectory via a Physics-Guided Diffusion Model
Zhang, Yiyuan; Hua, Cailong; Singh, Vinitendra; Muretta, Joseph M.; Ervasti, James M.; Salapaka, Murti V.
Proceedings of the 43rd International Conference on Machine Learning (ICML), PMLR 306, Seoul, South Korea (2026). · 2026
-
Topology Change Estimation in Power Distribution Networks: A Machine Learning Approach
Dey, Arnab; Chakraborty, Soham; Salapaka, Murti V.
IEEE Transactions on Smart Grid 17, no. 4 (July 2026): 3445. · 2026
-
Learning Topology of Meshed Microgrids Using Voltage Magnitude.
Mohammed Tuhin Rana, and Murti V. Salapaka.
2025 IEEE Energy Conversion Conference Congress and Exposition (ECCE). IEEE · 2025
-
A Physics-Augmented Deep Learning Framework for Classifying Single Molecule Force Spectroscopy Data
Hua, Cailong; Rajaganapathy, Sivaraman; Slick, Rebecca A.; Vavra, Joseph; Muretta, Joseph M.; Ervasti, James M.; Salapaka, Murti V.
Proceedings of Machine Learning Research (PMLR) 267 (2025): 24950–24974. · 2025
Content coming in later sessions
Featured work
Flagship papers in this area. Session 3 (CV import).
Current members
People working in this area. Session 4.
Alumni placements
Where alumni who worked in this area now are. Session 4.
Recent news
Highlights tagged to this area. Session 5.
Facilities used
Equipment and testbeds enabling this area. Session 5.
This lab also works in
-
Theoretical Foundations
UmbrellaControl theory, network structure and causal discovery, distributed optimization, nonlinear dynamics, thermodynamics at the small scale.
-
Energy
Distributed control, grid-forming inverters, cyber-secure microgrids, and renewable integration.
-
Nanoscience
AFM, optical tweezers, probe-based data storage, and quantitative real-time nano-imaging.
-
Single-Molecule Biophysics
Motor proteins, cargo transport, force spectroscopy of dystrophin and utrophin, and the biophysics of cellular systems studied one molecule at a time.
Interested in joining this area?
The lab welcomes prospective PhD students and postdocs.
Learn how to join